Xeltin (Tofacitinib) Tablets uses

Xeltin (Tofacitinib) Tablets – Information

Disclaimer: This information is for educational purposes only. Tofacitinib is a powerful prescription drug. It must only be used under the strict supervision and advice of a qualified doctor. Do not self-medicate.

1. Composition (Active Ingredient):

• The active ingredient in Xelten tablets is Tofacitinib Citrate.
• It belongs to a class of drugs known as JAK inhibitors (Janus Kinase inhibitors). It works by modulating the immune system, which is overactive in autoimmune diseases.

2. Uses (Indications):

Tofacitinib is used to treat moderate to severe active autoimmune diseases in specific situations, often when other treatments have not worked. Its uses include:

• Rheumatoid Arthritis (RA): For adults who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
• Psoriatic Arthritis (PsA): For active psoriatic arthritis in patients who have had an inadequate response or intolerance to a prior DMARD.
• Ulcerative Colitis (UC): For moderately to severely active ulcerative colitis in patients who have had an inadequate response or intolerance to other therapies.
• Ankylosing Spondylitis (AS): For active ankylosing spondylitis in patients who have had an inadequate response to conventional therapy.

3. Side Effects:

Because Tofacitinib affects the immune system, it can cause serious side effects. Notify your doctor immediately if you experience any new or worsening symptoms.

Common Side Effects:

• Headache
• Diarrhea
• Common cold (nasopharyngitis)
• Upper respiratory tract infections
• Rash
• Nausea

Serious Side Effects (Seek immediate medical attention):

• Serious Infections: This drug significantly increases the risk of serious and potentially fatal infections (bacterial, viral, fungal, including tuberculosis). Watch for signs like fever, sweating, chills, muscle aches, cough, shortness of breath, blood in phlegm, weight loss, warm/red/skin sores.
• Cancer (Malignancies): There is an increased risk of certain cancers, including lymphoma, lung cancer, and skin cancers. Regular skin exams are recommended.
• Blood Clots: Increased risk of blood clots in the veins (deep vein thrombosis – DVT) and lungs (pulmonary embolism – PE). Symptoms include sudden shortness of breath, chest pain, leg pain or swelling.
• Cardiovascular Events: Increased risk of major adverse cardiovascular events (e.g., heart attack, stroke) in high-risk patients.
• Gastrointestinal Perforations: Can cause tears in the stomach or intestines.
• Changes in Lab Results: Can increase cholesterol and liver enzyme levels and decrease blood cell counts (neutrophils, lymphocytes, hemoglobin).

4. Important Warnings & Precautions:

• Infections: Do not start this medication if you have any active infection. Your doctor should test you for tuberculosis (TB) and other infections before and during treatment.
• Vaccines: Avoid live vaccines (e.g., MMR, chickenpox, nasal flu vaccine) while taking Tofacitinib.
• Pregnancy & Breastfeeding: Not recommended. Discuss the risks and benefits with your doctor.
• Other Medications: Inform your doctor about all other medicines you take, including over-the-counter drugs and supplements, as they may interact with Tofacitinib.
• Kidney or Liver Problems: Dosage adjustment may be necessary if you have kidney or liver impairment.

Final Advice: Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without their advice. Regular monitoring and blood tests are essential while on this medication.