Introduction

Aspirin is one of the oldest and most widely used medicines in the world.
It belongs to the group NSAIDs (non-steroidal anti-inflammatory drugs).
It is used for pain relief, fever reduction, anti-inflammation, and at low doses as a blood thinner (antiplatelet agent) to prevent heart attacks and strokes.

🔹 Composition

Generic Name: Acetylsalicylic Acid (ASA)
Available Strengths in Pakistan:
- Low-dose (75 mg, 81 mg, 100 mg) → mostly for heart & blood clot prevention.
- Regular dose (300 mg, 500 mg) → for pain, fever, inflammation.

🔹 Uses

Cardiovascular Protection
- Prevents heart attacks, strokes, transient ischemic attacks (TIAs).
- Used after angioplasty, bypass surgery, or in patients with angina.
Pain Relief & Anti-inflammatory
- Headache, toothache, muscle pain, arthritis, back pain.
Fever Reduction
- Lowers fever in infections (though paracetamol is usually preferred now).
Other Medical Uses
- Sometimes used in rheumatic fever, Kawasaki disease, or pre-eclampsia (under medical supervision).

🔹 Side Effects

While effective, aspirin has some risks:

Gastrointestinal (commonest)
- Stomach upset, acidity, nausea, vomiting.
- Gastric ulcer, internal bleeding (serious).
Bleeding tendency
- Nosebleeds, bruising, prolonged bleeding.
- Rare but serious: brain hemorrhage.
Allergic reactions
- Rash, swelling, asthma attack (aspirin-sensitive asthma).
Other
- Tinnitus (ringing in ears) at high doses.
- Kidney/liver issues if used long-term.
- Not recommended in children/teens with viral illness → risk of Reye’s Syndrome.

🔹 Popular Brands in Pakistan

Some widely available aspirin brands (low-dose & regular) include:

Brand Name	Manufacturer
Ascard (75 mg)	ATCO Laboratories
Loprin (75 mg)	Highnoon Laboratories
Disprin (300 mg, 500 mg)	Reckitt Benckiser
Anaprin	Opal Laboratories
Angipro	Unimark
Anticlot	Euro Pharma
Aspisafe	Zafa Pharmaceuticals

✅ Note: Always take aspirin with food to reduce stomach irritation, and only under a doctor’s advice if you’re using it for heart protection or long-term therapy.

Here’s a comparison table of Low-Dose vs High-Dose Aspirin so you can quickly see the difference in uses, strengths, and risks:

Feature	Low-Dose Aspirin	High-Dose Aspirin
Common Strengths	75 mg, 81 mg, 100 mg	300 mg, 500 mg (sometimes 600 mg)
Main Purpose	Blood thinner (antiplatelet) – prevents clot formation	Pain relief, fever reduction, inflammation control
Typical Uses	• Prevention of heart attack & stroke • After angioplasty / bypass surgery • Patients with angina or ischemic heart disease	• Headache, toothache, backache • Muscle pain, arthritis, rheumatic fever • Fever in infections (though paracetamol preferred)
Mechanism of Action	Irreversible inhibition of platelets (via COX-1 & thromboxane A₂ blockade)	Inhibits prostaglandins → reduces pain, fever, inflammation
Dosage Frequency	Once daily (usually at night or morning)	Every 4–6 hours as needed (depending on pain/fever)
Side Effects	• Gastric irritation, bleeding risk • Easy bruising, nosebleeds • Not for children with viral illness (Reye’s syndrome)	• More GI upset & ulcers • Higher risk of stomach/intestinal bleeding • Tinnitus (ringing in ears) at high doses • Kidney/liver effects with prolonged use
Who Uses It Most	Heart patients, hypertensive & diabetic patients at high CV risk, post-stent patients	General population for pain & fever (OTC use), arthritis patients
Examples (Pakistan)	Ascard, Loprin, Anaprin, Anticlot, Aspisafe	Disprin, Aspirin (generic), various 300–500 mg brands

Also See
Augmentin Uses and side effects

Sehat Guide

Aspirin uses and side effects

Table of Contents

Introduction

🔹 Composition

🔹 Uses

🔹 Side Effects

🔹 Popular Brands in Pakistan

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